Before you take this medicine, tell your doctor if you have liver or kidney disease, asthma, glaucoma, an enlarged prostate, or urination problems. You should not take this medication if you are allergic to meclizine. Meclizine is a first-generation antihistamine (nonselective H1 antagonist) of the piperazine class. It is structurally and pharmacologically similar to buclizine, cyclizine, and hydroxyzine.
Related treatment guides
There is limited information regarding Patient Counseling Information of Meclizine in the drug label. There is limited information regarding Meclizine Storage in the drug label. There is limited information regarding Clinical Studies of Meclizine in the drug label.
FDA-Labeled Indications and Dosage (Adult)
Another suggests the eyes mostly see the interior of the car which is motionless while the vestibular system of the inner ear senses motion as the vehicle goes around corners or over hills and even small bumps. Therefore, the effect is worse when looking down but may be lessened by looking outside of the vehicle. Common side effects are Drowsiness, dry mouth, and on rare occasions, blurred vision have been reported. Meclizine may trigger drowsiness, fatigue, and dry mouth. In case that happens it is important to immediately contact a physician.
Adverse Effects
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use meclizine only for the indication prescribed. Take meclizine exactly as prescribed by your doctor.
There is limited information regarding Pharmacodynamics of Meclizine in the drug label. There is limited information regarding IV Compatibility of Meclizine in the drug label. There is limited information regarding Monitoring of Meclizine in the drug label. There is limited information regarding Postmarketing Experience of Meclizine in the drug label.
- You may take meclizine once every 24 hours while you are traveling, to further prevent motion sickness.
- It is not known if or how meclizine could affect pregnancy or harm an unborn baby.
- This activity discusses the various facets of meclizine, offering insights into its indications, mechanism of action, contraindications, interactions, and adverse events.
- There is limited information regarding Monitoring of Meclizine in the drug label.
- Meclizine is most effective if taken before symptoms appear.
Virtual reality to reverse motion sickness
If you are on a dosing schedule, skip any missed dose. You should not use meclizine if you are allergic to it. Be careful if you drive or do anything that requires you to be alert.
Histamine H1 receptors are expressed on the vestibular nuclei and nucleus of the solitary tract (NTS) that are activated by motion sickness and stimuli from the pharynx and stomach. When activated, H1 receptor signaling from these nuclei is transmitted to the CTZ and vomiting centre. Meclizine is used to prevent nausea, vomiting, dizziness and motion sickness. Sometimes, it is also used to treat nausea in pregnancy and that triggered by exposure to radiation. Meclizine is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness.
- WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling.
- It is structurally and pharmacologically similar to buclizine, cyclizine, and hydroxyzine.
- Common side effects are Drowsiness, dry mouth, and on rare occasions, blurred vision have been reported.
- Before you take this medicine, tell your doctor if you have liver or kidney disease, asthma, glaucoma, an enlarged prostate, or urination problems.
- Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by meclizine.
Meclizine shows no risk of birth defects or abnormalities when administered during pregnancy. Although Meclizine may excrete into the milk, it causes no harm in nursing babies. Meclizine has a plasma elimination half-life of about 5-6 hours in humans. The volume of distribution of meclizine in humans has not been fully studied.
The lowest published toxic dose (TDLo) in rats via the oral route is 800 mg/kg. There is limited information regarding Off-Label Non–Guideline-Supported Use of Meclizine in pediatric patients. There is limited information regarding Off-Label Guideline-Supported Use of Meclizine in pediatric patients. There is limited information regarding FDA-Labeled Use of Meclizine in pediatric patients. There is limited information regarding Off-Label Guideline-Supported Use of Meclizine in adult patients. There are no known interactions between meclizine and foods or drinks.
It is not known if or how meclizine could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. If meclizine is prescribed to you by a healthcare provider, take it as prescribed. If you take over-the-counter (OTC) meclizine, follow the instructions for the product you are taking. Meclizine may cause allergic reactions, which can be serious.
Meclizine is most effective if taken before symptoms appear.
Medical uses
Call your doctor for medical advice about side effects. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. Cyclizine may be prepared by the Eschweiler–Clarke methylation of diphenylmethylpiperazine or by reaction of benzhydryl bromide meclizine wikipedia with 1-methylpiperazine in acetonitrile to form the hydrobromide salt of the drug.